During the Last Deglaciation, global surface temperature rose by about 4–7 °C over several millennia. We show that changes in year-to-year up to century-to-century fluctuations of temperature and precipitation during the Deglaciation were mostly larger than during either the preceding or succeeding more stable periods in 15 climate model simulations. The analysis demonstrates how ice sheets, meltwater, and volcanism influence simulated variability to inform future simulation protocols.