Dear authors,
Thank you for your comprehensive response to all the review comments. I would like to ask you to prepare and submit a revised manuscript in line with your responses. Please pay special attention to:
1) Structure and readability of the manuscript. Very good advice has been given by the reviewers how to better structure your manuscript. Please use it. If needed for the readability of a given section, please shortly introduce the logic of that section and reiterate the logic of a given experiment or analysis.
2) From the reviewer comments, it is clear that your experimental setup isn't standard. In itself that is not a bad thing, I think you have good reasons for it, but it does call for a very clear description of your approach. Perhaps you can also explicitly state in a dedicated section that your approach is different from what is mostly done and why you think this approach is needed.