A foraminifer oxygen isotope record from the northeastern Arabian Sea was used to reconstruct winter and summer monsoon strength from 5.4 to 3.0 ka. We found a 200-year period of strengthened winter monsoon (4.5–4.3 ka) that coincides with the earliest phase of the Mature Harappan period of the Indus Civilization, followed by weakened winter and summer monsoons by 4.1 ka. Aridity spanning both rainfall seasons at 4.1 ka may help to explain some of the observed archaeological shifts.