The Atlantic Multidecadal Oscillation (AMO) is prominent in the climate system. We study the AMO over the last 2000 years using a novel proxy framework, the Last Millennium Reanalysis. We find that the AMO is linked to continental warming, Arctic sea ice retreat, and an Atlantic precipitation shift. Low clouds decrease globally. We find no distinct multidecadal spectral peak in the AMO over the last 2 millennia, suggesting that human activities may have enhanced the AMO in the modern era.