Global cooling and a major expansion of ice over Antarctica occurred ~ 34 million years ago at the Eocene–Oligocene transition (EOT). A large secondary proxy dataset for high-latitude Southern Hemisphere temperature before, after and across the EOT is compiled and compared to simulations from two coupled climate models. Although there are inconsistencies between the models and data, the comparison shows amongst other things that changes in the Drake Passage were unlikely the cause of the EOT.